Transforming growth factor-β and interleukin-10 subvert alloreactive delayed type hypersensitivity in cardiac allograft acceptor mice

被引:37
作者
Bickerstaff, AA
VanBuskirk, AM
Wakely, E
Orosz, CG
机构
[1] Ohio State Univ, Coll Med, Dept Surg, Columbus, OH 43210 USA
[2] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43210 USA
[3] Ohio State Univ, Coll Med, Dept Med Microbiol & Immunol, Columbus, OH 43210 USA
[4] Ohio State Univ, Coll Med, Ctr Comprehens Canc, Columbus, OH 43210 USA
关键词
D O I
10.1097/00007890-200004150-00055
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have previously reported that temporary treat ment of cardiac allograft recipients with gallium nitrate (GN) results in indefinite graft survival, and the inability to mount donor-reactive delayed type hypersensitivity (DTH) responses. We report that antibodies to either transforming growth factor-beta (TGF beta) or interleukin-10 (IL10) can uncover DTH responses to donor alloantigens in cardiac allograft acceptor mice. The DTH responses uncovered with TGF beta-reactive antibodies can be blocked by exogenous IL10, and those uncovered with IL10-reactive antibodies can be blocked by exogenous TGF beta. These data demonstrate that allograft acceptor mice are fully allosensitized, and poised to make donor-reactive cell-mediated immune responses. However, such responses are subverted by a donor alloantigen-dependent mechanism that involves TGF beta and IL10, which in turn interfere with local cell-mediated immune responses.
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收藏
页码:1517 / 1520
页数:4
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