Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations

被引：9

作者：

Zhu, GS

Bartsch, O

Skrypnyk, C

Rotondo, A

Akhtar, LA

Harris, C

Virkkunen, M

Cassano, G

Goldman, D ^{[1
]}

机构：

[1] NIAAA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[2] Changhai Hosp, Shanghai 200433, Peoples R China

[3] Dresden Univ Technol, Inst Clin Genet, D-01307 Dresden, Germany

[4] Univ Oradea, Dept Genet, Oradea 3700, Romania

[5] Univ Pisa, Dept Psychiat, I-56100 Pisa, Italy

[6] Univ Helsinki, Dept Psychiat, SF-00180 Helsinki, Finland

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2004年 / 12卷 / 06期

基金：

美国国家卫生研究院;

关键词：

chromosomal duplication; panic disorder; fluorescence in situ hybridization; real-time PCR;

D O I：

10.1038/sj.ejhg.5201181

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Investigation of the co-occurrence of panic and phobic disorders with joint laxity led to the identification of interstitial duplications involving human chromosome 15q24 - 26 ( named 'DUP25') in a Spanish population. DUP25 was observed in 97% of patients and in 7% of control individuals. In the present study, we used two different methods to detect DUP25: high-throughput molecular gene dosage analysis and fluorescence in situ hybridization ( FISH). We evaluated 56 lymphoblastoid cell lines derived from 26 unrelated patients with panic disorder obtained from several European and American populations and 30 normal controls. We could not find any cell line showing a result consistent with DUP25. These data do not support any association of DUP25 with panic disorder.

引用

页码：505 / 508

页数：4

共 6 条

[1] FISH studies in 45 patients with Rubinstein-Taybi syndrome:: deletions associated with polysplenia, hypoplastic left heart and death in infancy [J].