Cytoskeletal Pathologies of Alzheimer Disease

被引:119
作者
Bamburg, James R. [1 ]
Bloom, George S. [2 ,3 ]
机构
[1] Colorado State Univ, Dept Biochem & Mol Biol, Mol Cellular & Integrat Neurosci Program, Ft Collins, CO 80523 USA
[2] Univ Virginia, Dept Biol, Charlottesville, VA USA
[3] Univ Virginia, Dept Cell Biol, Charlottesville, VA USA
来源
CELL MOTILITY AND THE CYTOSKELETON | 2009年 / 66卷 / 08期
关键词
Alzheimer disease; tau; microtubule; actin; cofilin; amyloid beta; PAIRED HELICAL FILAMENTS; AMYLOID PRECURSOR PROTEIN; ACTIN DEPOLYMERIZING FACTOR; CENTRAL-NERVOUS-SYSTEM; MICROTUBULE-ASSOCIATED PROTEIN-2; SHARE ANTIGENIC DETERMINANTS; GLYCOGEN-SYNTHASE KINASE-3; APOLIPOPROTEIN-E GENOTYPE; LONG-TERM POTENTIATION; A-BETA OLIGOMERS;
D O I
10.1002/cm.20388
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The histopathological hallmarks of Alzheimer disease are the extracellular amyloid plaques, composed principally of the amyloid beta peptide, and the intracellular neurofibrillary tangles, composed of paired helical filaments of the microtubule-associated protein, tau. Other histopathological structures involving actin and the actin-binding protein, cofilin, have more recently been recognized. Here we review new findings about these cytoskeletal pathologies, and, emphasize how plaques, tangles, the actin-containing inclusions and their respective building blocks may contribute to Alzheimer pathogenesis and the primary behavioral symptoms of the disease. Cell Motil. Cytoskeleton 66: 635-649, 2009. (C) 2009 Wiley-Liss. Inc.
引用
收藏
页码:635 / 649
页数:15
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