Primary bone osteosarcoma in the pediatric age: State of the art

被引:533
作者
Longhi, Alessandra [1 ]
Errani, Costantino [1 ]
De Paolis, Massimiliano [1 ]
Mercuri, Mario [1 ]
Bacci, Gaetano [1 ]
机构
[1] Ist Ortoped Rizzoli, Sezione Chemioterapia, Dept Oncol, I-40136 Bologna, Italy
关键词
pediatric osteosarcoma; chemotherapy; surgery; new drugs;
D O I
10.1016/j.ctrv.2006.05.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The current combination treatment, chemotherapy and surgery, has significantly improved the cure rate and the survival rate of primary bone osteosarcoma. The 5-year survival rate has increased in the last 30 years from 10% to 70%. Even in patients with poor prognosis, such as those with metastases at diagnosis, the 5-year survival rate has reached 20-30% due to chemotherapy and the surgical removal of metastases and primary tumor. However, the most effective drugs are still the same as those employed over the last 20 years as front tine neoadjuvant or adjuvant chemotherapy: Doxorubicin, Cisplatin, Methotrexate, Ifosfamide. No standard, second tine therapy exists for those who relapse. At relapse, due to the tack of new non-cross-resistant drugs, surgery is still the main option when feasible. Other drugs have been employed in relapsed patients with poor results. This article reviews the state of the art of treatment for bone osteosarcoma in the pediatric age. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:423 / 436
页数:14
相关论文
共 175 条
[1]   The surgical treatment and outcome of pathological fractures in localised osteosarcoma [J].
Abudu, A ;
Sferopoulos, NK ;
Tillman, RM ;
Carter, SR ;
Grimer, RJ .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1996, 78B (05) :694-698
[2]   MRI AND CT EVALUATION OF PRIMARY BONE AND SOFT-TISSUE TUMORS [J].
AISEN, AM ;
MARTEL, W ;
BRAUNSTEIN, EM ;
MCMILLIN, KI ;
PHILLIPS, WA ;
KLING, TF .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1986, 146 (04) :749-756
[3]   MASSIVE ALLOGRAFTS IN THE TREATMENT OF OSTEOSARCOMA AND EWING SARCOMA IN CHILDREN AND ADOLESCENTS [J].
ALMAN, BA ;
DEBARI, A ;
KRAJBICH, JI .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1995, 77A (01) :54-64
[4]   High-dose samarium-153 ethylene diamine tetramethylene phosphonate: Low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases [J].
Anderson, PM ;
Wiseman, GA ;
Dispenzieri, A ;
Arndt, CAS ;
Hartmann, LC ;
Smithson, WA ;
Mullan, BP ;
Bruland, OS .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (01) :189-196
[5]  
Arndt C, 1999, MED PEDIATR ONCOL, V32, P93, DOI 10.1002/(SICI)1096-911X(199902)32:2<93::AID-MPO4>3.0.CO
[6]  
2-Y
[7]   Metachronous skeletal osteosarcoma in patients treated with adjuvant and neoadjuvant chemotherapy for nonmetastatic osteosarcoma [J].
Aung, L ;
Gorlick, R ;
Healey, JH ;
Ski, WJ ;
Thaler, HT ;
Shorter, NA ;
Huvos, AG ;
Meyers, PA .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (02) :342-348
[8]   Second malignant neoplasms in long-term survivors of osteosarcoma - Memorial sloan-kettering cancer center experience [J].
Aung, L ;
Gorlick, RG ;
Shi, W ;
Thaler, H ;
Shorter, NA ;
Healey, JH ;
Huvos, AG ;
Meyers, PA .
CANCER, 2002, 95 (08) :1728-1734
[9]  
AVELLA M, 1988, CHEMIOTERAPIA, V7, P133
[10]   Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity - Histologic response to preoperative chemotherapy correlates with histologic subtype of the tumor [J].
Bacci, G ;
Bertoni, F ;
Longhi, A ;
Ferrari, S ;
Forni, C ;
Biagini, R ;
Bacchini, P ;
Donati, D ;
Manfrini, M ;
Bernini, G ;
Lari, S .
CANCER, 2003, 97 (12) :3068-3075