Social and novel contexts modify hippocampal CA2 representations of space

被引:132
作者
Alexander, Georgia M. [1 ]
Farris, Shannon [1 ]
Pirone, Jason R. [2 ,5 ]
Zheng, Chenguang [3 ,4 ]
Colgin, Laura L. [3 ,4 ]
Dudek, Serena M. [1 ]
机构
[1] NIEHS, Neurobiol Lab, NIH, 111 TW Alexander Dr,Mail Drop F2-04, Res Triangle Pk, NC 27709 USA
[2] Social & Sci Syst Inc, 1009 Slater Rd,Suite 120, Durham, NC 27703 USA
[3] Univ Texas Austin, Ctr Learning & Memory, 1 Univ Stn Stop C7000,NMS 4-104, Austin, TX 78712 USA
[4] Univ Texas Austin, Dept Neurosci, Austin, TX 78712 USA
[5] SciOme LLC, 2 Davis Dr, Res Triangle Pk, NC 27709 USA
基金
美国国家卫生研究院;
关键词
MESSENGER RIBONUCLEIC-ACIDS; IMMEDIATE-EARLY GENES; SYNAPTIC PLASTICITY; VASOPRESSIN V1B; RAT HIPPOCAMPUS; DENTATE GYRUS; UNIT-ACTIVITY; 1B RECEPTOR; CELLS; AREA;
D O I
10.1038/ncomms10300
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentation of a social stimulus (novel or familiar rat) or a novel object induces global remapping of place fields in CA2 with no effect on neuronal firing rate or immediate early gene expression. This remapping did not occur in CA1, suggesting this effect is specific for CA2. Thus, modification of existing spatial representations might be a potential mechanism by which CA2 encodes social and novel contextual information.
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页数:14
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