The Bioenergetic Health Index: a new concept in mitochondrial translational research

被引：265

作者：

Chacko, Balu K. ^{[1
,2
]}

Kramer, Philip A. ^{[1
,2
]}

Ravi, Saranya ^{[1
,2
]}

Benavides, Gloria A. ^{[1
,2
]}

Mitchell, Tanecia ^{[1
,2
]}

Dranka, Brian P. ^{[3
]}

Ferrick, David ^{[3
]}

Singal, Ashwani K. ^{[4
]}

Ballinger, Scott W. ^{[1
,2
]}

Bailey, Shannon M. ^{[2
]}

Hardy, Robert W. ^{[1
,2
]}

Zhang, Jianhua ^{[1
,2
,5
]}

Zhi, Degui ^{[6
]}

Darley-Usmar, Victor M. ^{[1
,2
]}

机构：

[1] Univ Alabama Birmingham, Mitochondrial Med Lab, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[3] Seahorse Biosci, North Billerica, MA 01862 USA

[4] Univ Alabama Birmingham, Dept Internal Med, Div Gastroenterol & Hepatol, Birmingham, AL 35294 USA

[5] Med Ctr, Dept Veteran Affairs, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA

来源：

CLINICAL SCIENCE | 2014年 / 127卷 / 5-6期

基金：

美国国家卫生研究院;

关键词：

aging; cardiovascular disease; haplotype; hepatotoxicity; neurodegenerative disease; oxidative stress; reserve capacity; BLOOD MONONUCLEAR-CELLS; METABOLIC SYNDROME; DYSFUNCTION; DISEASE; DIFFERENTIATION; LYMPHOCYTES; HOMEOSTASIS; APOPTOSIS; PROFILES; CAPACITY;

D O I：

10.1042/CS20140101

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the 'canary in the coal mine' by serving as an early warning of bioenergetic crisis in patient populations. We propose that new clinical tests to monitor changes in bioenergetics in patient populations are needed to take advantage of the early and sensitive ability of bioenergetics to determine severity and progression in complex and multifactorial diseases. With the recent development of high-throughput assays to measure cellular energetic function in the small number of cells that can be isolated from human blood these clinical tests are now feasible. We have shown that the sequential addition of well-characterized inhibitors of oxidative phosphorylation allows a bioenergetic profile to be measured in cells isolated from normal or pathological samples. From these data we propose that a single value the Bioenergetic Health Index (BHI) can be calculated to represent the patient's composite mitochondrial profile for a selected cell type. In the present Hypothesis paper, we discuss how BHI could serve as a dynamic index of bioenergetic health and how it can be measured in platelets and leucocytes. We propose that, ultimately, BHI has the potential to be a new biomarker for assessing patient health with both prognostic and diagnostic value.

引用

页码：367 / 373

页数：7

共 39 条

[1]

Blake R., 2013, BIOCHIM BIOPHYS ACTA, V1840, P1404

[2] Assessing mitochondrial dysfunction in cells [J].