Cancer: Addiction to oncogenes - The Achilles heal of cancer

被引：1384

作者：

Weinstein, IB ^{[1
]}

机构：

[1] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

SCIENCE | 2002年 / 297卷 / 5578期

关键词：

D O I：

10.1126/science.1073096

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

引用

页码：63 / 64

页数：3

共 21 条

[1]

Aoki K, 1997, MOL CARCINOGEN, V20, P251, DOI 10.1002/(SICI)1098-2744(199710)20:2<251::AID-MC12>3.3.CO

[2]

2-P

[3]

Essential role for oncogenic Ras in tumour maintenance [J].

Chin, L ;

Tam, A ;

Pomerantz, J ;

Wong, M ;

Holash, J ;

Bardeesy, N ;

Shen, Q ;

O'Hagan, R ;

Pantginis, J ;

Zhou, H ;

Horner, JW ;

Cordon-Cardo, C ;

Yancopoulos, GD ;

DePinho, RA .

NATURE, 1999, 400 (6743) :468-472

[4]

ERBB-2 ANTISENSE OLIGONUCLEOTIDES INHIBIT THE PROLIFERATION OF BREAST-CARCINOMA CELLS WITH ERBB-2 ONCOGENE AMPLIFICATION [J].

COLOMER, R ;

LUPU, R ;

BACUS, SS ;

GELMANN, EP .

BRITISH JOURNAL OF CANCER, 1994, 70 (05) :819-825

[5]

CRUZ CC, 2001, NAT MED, V7, P235

[6]

Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen [J].

Ewald, D ;

Li, MG ;

Efrat, S ;

Auer, G ;

Wall, RJ ;

Furth, PA ;

Hennighausen, L .

SCIENCE, 1996, 273 (5280) :1384-1386

[7]

Reversible tumorigenesis by MYC in hematopoietic lineages [J].

Felsher, DW ;

Bishop, JM .

MOLECULAR CELL, 1999, 4 (02) :199-207

[8]

Transient excess of MYC activity can elicit genomic instability and tumorigenesis [J].

Felsher, DW ;

Bishop, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3940-3944

[9]

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification [J].

Gorre, ME ;

Mohammed, M ;

Ellwood, K ;

Hsu, N ;

Paquette, R ;

Rao, PN ;

Sawyers, CL .

SCIENCE, 2001, 293 (5531) :876-880

[10]

The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

← 1 2 3 →