Lithium perchlorate mediated three-component preparation of α-aminonitriles under solvent-free conditions

被引：13

作者：

Azizi, N ^{[1
]}

Saidi, MR ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 07期

关键词：

lithium perchlorate; alpha-aminonitriles; solvent-free conditions; three-component condensation;

D O I：

10.1081/SCC-120030307

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component reaction between aliphatic or aromatic aldehyde, an amine and trimethylsilyl cyanide mediated by solid LiClO4, gave amino nitriles in good to excellent yields. The reaction proceeded smoothly under solvent-free conditions without any side products.

引用

页码：1207 / 1214

页数：8

共 25 条

[1] Arend M, 1998, ANGEW CHEM INT EDIT, V37, P1044, DOI 10.1002/(SICI)1521-3773(19980504)37:8<1044::AID-ANIE1044>3.0.CO
[2] 2-E
[3] A new protocol for the Baylis-Hillman reaction: the reaction of iminium salts prepared in situ with methyl acrylate
Azizi, N
Saidi, MR
[J]. TETRAHEDRON LETTERS, 2002, 43 (24) : 4305 - 4308
[4] Bohme H., 1976, ADV ORG CHEM 1, V9, P107
[5] Amino acid derivatives by multicomponent reactions
Dyker, G
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (16): : 1700 - 1702
[6] HARUSAWA S, 1979, TETRAHEDRON LETT, P4663
[7] Catalytic enantioselective addition to imines
Kobayashi, S
Ishitani, H
[J]. CHEMICAL REVIEWS, 1999, 99 (05) : 1069 - 1094
[8] Enhancement of the diastereoselectivity in the addition of trimethylsilyl cyanide to chiral aldimines by catalysis with a chiral 1,2-diamine: unexpected mechanistic results
Leclerc, E
Mangeney, P
Henryon, V
[J]. TETRAHEDRON-ASYMMETRY, 2000, 11 (17) : 3471 - 3474
[9] Enantioselective acylation of α-aminonitriles catalysed by Candida antarctica lipase.: An unexpected turnover-related racemisation
López-Serrano, P
Jongejan, JA
van Rantwijk, F
Sheldon, RA
[J]. TETRAHEDRON-ASYMMETRY, 2001, 12 (02) : 219 - 228
[10] FACILE SYNTHESIS OF ALPHA-AMINONITRILES
MAI, K
PATIL, G
[J]. TETRAHEDRON LETTERS, 1984, 25 (41) : 4583 - 4586

← 1 2 3 →