Polymer surfaces derivatized with poly(vinyl-N-hexylpyridinium) kill airborne and waterborne bacteria

被引：277

作者：

Tiller, JC

Lee, SB

Lewis, K

Klibanov, AM ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] Northeastern Univ, Dept Biol, Boston, MA 02115 USA

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 2002年 / 79卷 / 04期

关键词：

bactericidal; antibacterial; polycation; surface derivatization; nanocoating; synthetic polymers;

D O I：

10.1002/bit.10299

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A facile methodology has been developed for covalently derivatizing the surfaces of common materials with a designed antibacterial polycation, poly(vinyl-pyridinium bromide), wherein the first, key step involves surface coating with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner become bactericidal-they kill up to 99% of deposited, from either an aerosol or an aqueous suspension, Gram-positive and Gram-negative bacteria on contact. (C) 2002 Wiley Periodicals, Inc.

引用

页码：465 / 471

页数：7

共 19 条

[1] Surface finishes on stainless steel reduce bacterial attachment and early biofilm formation: Scanning electron and atomic force microscopy study [J].