Lack of activity of orally administered clofazimine against intracellular Mycobacterium tuberculosis in whole-blood culture

被引：20

作者：

Janulionis, E ^{[1
]}

Sofer, C ^{[1
]}

Song, HY ^{[1
]}

Wallis, RS ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Newark, NJ 07103 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 08期

关键词：

D O I：

10.1128/AAC.48.8.3133-3135.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity of oral clofazimine against intracellular Mycobacterium tuberculosis was compared to that of ofloxacin in healthy volunteers by the use of whole-blood cultures. Clofazimine was inactive whether it was tested alone or combined with other drugs that are used to treat multidrug-resistant tuberculosis, despite a total dose of 2 g. Kanamycin was the most active drug tested.

引用

页码：3133 / 3135

页数：3

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