Ovarian cancer in younger vs older women: a population-based analysis

被引:125
作者
Chan, J. K.
Urban, R.
Cheung, M. K.
Osann, K.
Husain, A.
Teng, N. N.
Kapp, D. S.
Berek, J. S.
Leiserowitz, G. S.
机构
[1] Stanford Univ, Dept Obstet & Gynecol, Div Gynecol Oncol, Sch Med, Stanford, CA 94305 USA
[2] Div Radiat Oncol, Stanford, CA 94305 USA
[3] Stanford Canc Ctr, Stanford, CA 94305 USA
[4] Univ Calif Irvine, Div Hematol Oncol, Chao Family Comprehens Canc Ctr, Med Ctr, Orange, CA 92868 USA
[5] Univ Calif Davis, Ctr Canc, Div Gynecol Oncol, Sacramento, CA 95817 USA
关键词
ovarian cancer; young; uterine-sparing; survival;
D O I
10.1038/sj.bjc.6603457
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To compare the clinico-pathologic prognostic factors and survival of younger vs older women diagnosed with epithelial ovarian cancer. Demographic, clinico-pathologic, treatment, and surgery information were obtained from patients with ovarian cancer from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001 and analysed using Kaplan-Meier estimates. Of 28 165 patients, 400 were < 30 years (very young), 11 601 were 30-60 (young), and 16 164 were 460 (older) years of age. Of the very young, young, and older patients, 261 (65.3%), 4664 (40.2%), and 3643 (22.5%) had stage I-II disease, respectively (P < 0.001). Across all stages, very young women had a significant survival advantage over the young and older groups with 5-year disease-specific survival estimates at 78.8% vs 58.8 and 35.3%, respectively (P < 0.001). This survival difference between the age groups persists even after adjusting for race, stage, grade, and surgical treatment. Reproductive age (16-40 years) women with stage I-II epithelial ovarian cancer who received uterine-sparing procedures had similar survivals compared to those who underwent standard surgery (93.3% vs 91.5%, P = 0.26). Younger women with epithelial ovarian cancer have a survival advantage compared to older patients.
引用
收藏
页码:1314 / 1320
页数:7
相关论文
共 54 条
[1]  
AVERETTE HE, 1995, CANCER, V76, P1096, DOI 10.1002/1097-0142(19950915)76:6<1096::AID-CNCR2820760626>3.0.CO
[2]  
2-4
[3]   Ovarian cancer: Changes in patterns at diagnosis and relative survival over the last three decades [J].
Barnholtz-Sloan, JS ;
Schwartz, AG ;
Qureshi, F ;
Jacques, S ;
Malone, J ;
Munkarah, AR .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2003, 189 (04) :1120-1127
[4]   Is breast cancer in young Latinas a different disease? [J].
Biffl, WL ;
Myers, A ;
Franciose, RJ ;
Gonzalez, RJ ;
Darnell, D .
AMERICAN JOURNAL OF SURGERY, 2001, 182 (06) :596-600
[5]   Long-term results and prognostic factors in patients with epithelial ovarian cancer [J].
Brun, JL ;
Feyler, A ;
Chêne, G ;
Saurel, J ;
Brun, G ;
Hocké, C .
GYNECOLOGIC ONCOLOGY, 2000, 78 (01) :21-27
[6]   Differences in prognostic molecular markers between women over and under 45 years of age with advanced ovarian cancer [J].
Chan, JK ;
Loizzi, V ;
Magistris, A ;
Lin, F ;
Rutgers, J ;
Osann, K ;
DiSaia, PJ ;
Berman, ML .
CLINICAL CANCER RESEARCH, 2004, 10 (24) :8538-8543
[7]   Stages III and IV invasive epithelial ovarian carcinoma in younger versus older women: What prognostic factors are important? [J].
Chan, JK ;
Loizzi, V ;
Lin, YG ;
Osann, K ;
Brewster, WR ;
DiSaia, PJ .
OBSTETRICS AND GYNECOLOGY, 2003, 102 (01) :156-161
[8]  
Cooper GS, 2002, MED CARE, V40, P43
[9]  
Dubsky Peter C, 2002, Clin Breast Cancer, V3, P65, DOI 10.3816/CBC.2002.n.013
[10]  
Duska LR, 1999, CANCER, V85, P2623, DOI 10.1002/(SICI)1097-0142(19990615)85:12<2623::AID-CNCR19>3.0.CO