Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection - The Hawaii Aging with HIV Cohort

被引：90

作者：

Valcour, Victor

Yee, Priscilla

Williams, Andrew E.

Shiramizu, Bruce

Watters, Michael

Selnes, Ola

Paul, Robert

Shikuma, Cecilia

Sacktor, Ned

机构：

[1] Univ Hawaii, Hawaii AIDS Clin Res Program, Honolulu, HI 96822 USA

[2] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA

[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[4] Univ Missouri, Dept Psychol, Div Behav Neurosci, St Louis, MO 63121 USA

来源：

JOURNAL OF NEUROVIROLOGY | 2006年 / 12卷 / 05期

关键词：

AIDS dementia complex; CD4 lymphocyte count; polyneuropathies;

D O I：

10.1080/13550280600915339

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r=.90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P=.005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P <.001).

引用

页码：387 / 391

页数：5

共 19 条

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