P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders

被引：45

作者：

Carlson, SR ^{[1
]}

Iacono, WG ^{[1
]}

McGue, M ^{[1
]}

机构：

[1] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA

来源：

BIOLOGICAL PSYCHOLOGY | 2002年 / 61卷 / 1-2期

关键词：

P300; amplitude; alcohol abuse/dependence; discordant twins; biological markers; endophenotype;

D O I：

10.1016/S0301-0511(02)00059-5

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The sons of alcoholics have repeatedly been found to have reduced P300 amplitude. Further, quantitative behavioral genetic and molecular genetic studies indicating a genetic influence on P300 amplitude have fueled speculation that this component may be a biological vulnerability marker for alcoholism. To further explore this possibility, we examined P300 in adolescent twin pairs from an epidemiological sample who were (a) discordant for alcohol abuse/dependence, (b) concordant for alcohol abuse/dependence, or (c) concordant for the absence of alcohol abuse/dependence and other relevant disorders. For discordant pairs, the alcohol abusing/dependent twins' amplitude did not differ from that of non-alcoholic co-twins. Pairs free of psychopathology had greater amplitudes than both alcoholism discordant and concordant pairs. P300 amplitude was more similar in monozygotic than dizygotic discordant pairs, suggesting a genetic influence on P300 amplitude in this group. The findings are consistent with P300 amplitude being a marker of vulnerability to alcohol use disorders. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：203 / 227

页数：25

共 83 条

[1]

Almasy L, 1999, AM J MED GENET, V88, P383

[2] Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism [J].

Almasy, L ;

Porjesz, B ;

Blangero, J ;

Goate, A ;

Edenberg, HJ ;

Chorlian, DB ;

Kuperman, S ;

O'Connor, SJ ;

Rohrbaugh, J ;

Bauer, LO ;

Foroud, T ;

Rice, JP ;

Reich, T ;

Begleiter, H .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (01) :128-135

[3] The P300 brain potential is reduced in smokers [J].

Anokhin, AP ;

Vedeniapin, AB ;

Sirevaag, EJ ;

Bauer, LO ;

O'Connor, SJ ;

Kuperman, S ;

Porjesz, B ;

Reich, T ;

Begleiter, H ;

Polich, J ;

Rohrbaugh, JW .

PSYCHOPHARMACOLOGY, 2000, 149 (04) :409-413

[4]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[5] P300 DIFFERENCES BETWEEN NONALCOHOLIC YOUNG MEN AT AVERAGE AND ABOVE-AVERAGE RISK FOR ALCOHOLISM - EFFECTS OF DISTRACTION AND TASK MODALITY [J].

BAUER, L ;

HESSELBROCK, VM ;

OCONNOR, S ;

ROBERTS, L .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1994, 18 (02) :263-277

[6] Subtypes of family history and conduct disorder: Effects on p300 during the stroop test [J].

Bauer, LO ;

Hesselbrock, VM .

NEUROPSYCHOPHARMACOLOGY, 1999, 21 (01) :51-62

[7] FRONTAL P300 DECREMENTS IN ANTISOCIAL PERSONALITY-DISORDER [J].

BAUER, LO ;

OCONNOR, S ;

HESSELBROCK, VM .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1994, 18 (06) :1300-1305

[8] Frontal P300 decrements, childhood conduct disorder, family history, and the prediction of relapse among abstinent cocaine abusers [J].

Bauer, LO .

DRUG AND ALCOHOL DEPENDENCE, 1997, 44 (01) :1-10

[9] P300 decrements in teenagers with conduct problems: Implications for substance abuse risk and brain development [J].

Bauer, LO ;

Hesselbrock, VM .

BIOLOGICAL PSYCHIATRY, 1999, 46 (02) :263-272

[10] AUDITORY RECOVERY FUNCTION AND P3 IN BOYS AT HIGH-RISK FOR ALCOHOLISM [J].

BEGLEITER, H ;

PORJESZ, B ;

RAWLINGS, R ;

ECKARDT, M .

ALCOHOL, 1987, 4 (04) :315-321

← 1 2 3 4 5 6 7 8 9 →