Bioactive triterpenes from Diospyros blancoi

被引：18

作者：

Ragasa, Consolacion Y. ^{[1
]}

Anthony Puno, Marc Rhyan ^{[1
]}

Sengson, Josephine Marie Angeline P. ^{[1
]}

Shen, Chien-Chang ^{[2
]}

Rideout, John A. ^{[3
]}

Raga, Dennis D. ^{[4
]}

机构：

[1] De La Salle Univ, Dept Chem, Ctr Nat Sci & Ecol Res, Manila 1004, Philippines

[2] Natl Res Inst Chinese Med, Div Med Chem, Taipei 112, Taiwan

[3] Univ Cent Queensland, Dept Mol & Life Sci, Rockhampton, Qld 4701, Australia

[4] De La Salle Univ, Dept Biol, Ctr Nat Sci & Ecol Res, Manila 1004, Philippines

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 13期

关键词：

Diospyros blancoi; Ebenaceae; isoarborinol methyl ether; -amyrin palmitate; analgaesic; anti-inflammatory; antimicrobial; CARRAGEENAN; ESTERS; ACID;

D O I：

10.1080/14786410902951054

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of -amyrin palmitate, -amyrin palmitoleate, -amyrin palmitate and -amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.

引用

页码：1252 / 1258

页数：7

共 21 条

[1]

BRAIN-STEM LESIONS DISSOCIATE NEURAL MECHANISMS OF MORPHINE ANALGESIA IN DIFFERENT KINDS OF PAIN [J].

ABBOTT, FV ;

MELZACK, R .

BRAIN RESEARCH, 1982, 251 (01) :149-155

[2]

Fatty acid esters of triterpenes from Erythroxylum passerinum [J].

Barreiros, ML ;

David, JM ;

Pereira, PAD ;

Guedes, MLS ;

David, JP .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2002, 13 (05) :669-673

[3]

UNAMBIGUOUS ASSIGNMENT OF C-13 CHEMICAL-SHIFTS OF SOME HOPANE AND MIGRATED HOPANE DERIVATIVES BY 2D NMR [J].

CHAKRAVARTY, AK ;

MASUDA, K ;

SUZUKI, H ;

AGETA, H .

TETRAHEDRON, 1994, 50 (09) :2865-2876

[4]

Lanostane-type triterpenoids from Diospyros discolor [J].

Chen, Chiy-Rong ;

Cheng, Chao-Wen ;

Pan, Min-Hsiung ;

Liao, Yun-Wen ;

Tzeng, Chih-Ying ;

Chang, Chi-I .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (06) :908-911

[5]

FURTHER-STUDIES OF THE MECHANISM OF COUNTER IRRITATION BY TURPENTINE [J].

DAMAS, J ;

REMACLEVOLON, G ;

DEFLANDRE, E .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1986, 332 (02) :196-200

[6]

DERAEDT R, 1976, ARCH INT PHARMACOD T, V224, P30

[7]

RELEASE OF PROSTAGLANDINS-E AND PROSTAGLANDINS-F IN AN ALGOGENIC REACTION AND ITS INHIBITION [J].

DERAEDT, R ;

JOUQUEY, S ;

DELEVALLEE, F ;

FLAHAUT, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 61 (01) :17-24

[8]

Dimeric naphthoquinones from Diospyros discolor [J].

Ganapaty, S ;

Thomas, PS ;

Mallika, BN ;

Balaji, S ;

Karagianis, G ;

Waterman, PG .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2005, 33 (03) :313-315

[9]

WAX ESTERS AND TRITERPENE METHYL ETHERS FROM THE EXOCARP OF ELAEIS-GUINEENSIS [J].

GOH, SH ;

LAI, FL ;

GEE, PT .

PHYTOCHEMISTRY, 1988, 27 (03) :877-880

[10]

GUEVARA BQ, 1985, ACTA MANILANA S, P45

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