Interactions of hemoglobin with lecithin liposomes

被引：13

作者：

Xi, Juqun ^{[1
]}

Guo, Rong ^{[1
]}

Guo, Xia ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

COLLOID AND POLYMER SCIENCE | 2006年 / 284卷 / 10期

关键词：

lecithin liposome; hemoglobin; adsorption;

D O I：

10.1007/s00396-006-1492-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this paper, the interaction of hemoglobin (Hb) with lecithin liposomes is studied by UV-vis spectroscopy, fluorescent spectroscopy, and transmission electron microscopy. The adsorption of Hb on liposomes is likely to be related to the hydrophobic interaction between Hb and liposomes, which brings about the increase of the microenvironmental polarity (I-1/I-3) and the decrease of the fluorescence polarization (P) of lecithin liposomes. These results are considered to be that the adsorption of Hb on liposomes makes the spaces between the lecithin molecules increase, and a temporary gap is consequently formed in the liposomal bilayer membranes. The leakage of aqueous-space marker from the liposomes is increased with the addition of Hb.

引用

页码：1139 / 1145

页数：7

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