NMDA receptors, place cells and hippocampal spatial memory

被引：460

作者：

Nakazawa, K

McHugh, TJ

Wilson, MA

Tonegawa, S ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[2] MIT, Picower Ctr Learning & Memory, RIKEN MIT Neurosci Res Ctr, Ctr Canc Res, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

[4] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[5] NIMH, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2004年 / 5卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrn1385

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

N-methyl-D-aspartate receptors (NMDARs) in the rodent hippocampus have been shown to be essential for spatial learning and memory, and for the induction of long-term synaptic plasticity at various hippocampal synapses. In this review, we examine the evidence concerning the role of NMDARs in hippocampal memory processes, with an emphasis on the function of NMDARs in area CA1 of the hippocampus in memory acquisition, and the unique role of NMDARs in area CA3 in the rapid acquisition and associative retrieval of spatial information. Finally, we discuss the data that have emerged from in vivo hippocampal recording studies that indicate that the activity of hippocampal place cells during behaviour is an expression of a memory trace.

引用

页码：361 / 372

页数：12

共 170 条

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