Insulinotropic action of novel succinic acid esters

被引：17

作者：

Bjorkling, F

MalaisseLagae, F

Malaisse, WJ

机构：

[1] FREE UNIV BRUSSELS, EXPT MED LAB, B-1070 BRUSSELS, BELGIUM

[2] LEO PHARMACEUT PROD, DK-2750 BALLERUP, DENMARK

来源：

PHARMACOLOGICAL RESEARCH | 1996年 / 33卷 / 4-5期

关键词：

pancreatic islets; insulin release; succinic acid esters;

D O I：

10.1006/phrs.1996.0038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succinic acid. This indicates that it is possible to design esters of succinic acid which act as insulin secretagogues, while avoiding the undesirable generation of methanol that otherwise results from the use of either the monomethyl or dimethyl ester of this dicarboxylic acid. (C) 1996 The Italian Pharmacological Society.

引用

页码：273 / 275

页数：3

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