Palladium-Catalyzed Highly Diastereoselective Oxidative Cascade Cyclization Reactions

被引：60

作者：

Yip, Kai-Tai ^{[1
]}

Zhu, Nian-Yong ^{[1
]}

Yang, Dan ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 09期

关键词：

ASYMMETRIC HECK REACTION; MOLECULAR-OXYGEN; TANDEM CYCLIZATION; PALLADIUM(II)-CATALYZED OXIDATION; DOMINO REACTIONS; BOND FORMATION; C-N; INDOLES; ARYLATIONS; ALCOHOLS;

D O I：

10.1021/ol900355h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)(2)/disoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr > 24:1).

引用

页码：1911 / 1914

页数：4

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