Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry

被引：40

作者：

Augusti, DV

Augusti, R

Carazza, F

Cooks, RG ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Univ Fed Minas Gerais, Dept Chem, BR-31270901 Belo Horizonte, MG, Brazil

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 19期

关键词：

D O I：

10.1039/b204421h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rapid and simple chiral analysis of thalidomide solutions is demonstrated by using electrospray ionization tandem mass spectrometry and analysis of cluster ion dissociation by the kinetic method. Average deviations of 1% between the actual and experimental enantiomeric compositions are observed.

引用

收藏

页码：2242 / 2243

页数：2

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