Functions of Toll-like receptors: lessons from KO mice

被引：144

作者：

Akira, S ^{[1
]}

Takeda, K ^{[1
]}

机构：

[1] Osaka Univ, ERATO, Japan Sci & Technol Corp, Dept Host Def,Res Inst Microbial Dis, Suita, Osaka 5650871, Japan

来源：

COMPTES RENDUS BIOLOGIES | 2004年 / 327卷 / 06期

关键词：

Toll-like receptors; immune response; signaling pathway;

D O I：

10.1016/j.crvi.2004.04.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The innate immune response is a first-line defense system in which individual Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns (PAMPs) and exert subsequent immune responses against a variety of pathogens. TLRs are composed of an extracellular leucine-rich repeat (LRR) domain and a cytoplasmic domain that is homologous to that of the IL-1R family. Upon stimulation, TLR recruits a cytoplasmic adaptor molecule MyD88, then IL-1R-associated kinase (IRAK), and finally induces activation of NF-kappaB and MAP kinases. However, the responses to TLR ligands differ, indicating the diversity of TLR signaling pathways. Besides MyD88, several novel adaptor molecules have recently been identified. Differential utilization of these adaptor molecules may provide the specificity in the TLR signaling. (C) 2004 Academic des sciences. Published by Elsevier SAS. All rights reserved.

引用

页码：581 / 589

页数：9

共 43 条

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