Umbilical cord blood transplantation for acute myeloid leukemia

被引：9

作者：

Advani, Anjali S. ^{[1
]}

Laughlin, Mary J. ^{[2
]}

机构：

[1] Cleveland Clin, Lerner Coll Med, Dept Hematol Oncol & Blood Disorders, Taussig Canc Ctr, Cleveland, OH 44195 USA

[2] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2009年 / 16卷 / 02期

关键词：

acute myeloid leukemia; prognosis; umbilical cord blood transplant; UNRELATED DONORS; BONE-MARROW; PERIPHERAL-BLOOD; ADULT PATIENTS; STEM-CELLS; T-CELLS; RECIPIENTS; EXPANSION; MALIGNANCIES; ENGRAFTMENT;

D O I：

10.1097/MOH.0b013e3283257a60

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review To discuss the recent advances in the field of umbilical cord blood (UCB) transplant (UCBT) for the treatment of adult acute myeloid leukemia. This topic is particularly relevant given the increasing use of UCBT and the plethora of clinical and biological studies being done to further optimize UCBT. Recent findings We will focus on clinical outcomes, results of nonmyeloablative UCBT, graft-versus-leukemia effect and graft-versus-host disease, the effects of UCBT on the immune system, and the role of multiple UCBTs and ex-vivo expansion. Summary Ultimately, these findings and research will allow us to expand UCB to a larger number of patients. In addition, a better understanding of the biology of UCB and subsequent manipulation of UCB and the immune system will allow us to improve the graft-versus-leukemia effect, improve engraftment, and decrease infectious complications after transplant.

引用

页码：124 / 128

页数：5

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