Signaling the pathway to regeneration

被引：126

作者：

Snider, WD ^{[1
]}

Zhou, FQ ^{[1
]}

Zhong, J ^{[1
]}

Markus, A ^{[1
]}

机构：

[1] Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA

来源：

NEURON | 2002年 / 35卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(02)00762-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.

引用

页码：13 / 16

页数：4

共 24 条

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