Stem Cell States, Fates, and the Rules of Attraction

被引：252

作者：

Enver, Tariq ^{[5
]}

Pera, Martin ^{[3
]}

Peterson, Carsten ^{[4
,6
]}

Andrews, Peter W. ^{[1
,2
]}

机构：

[1] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England

[2] Univ Sheffield, Ctr Stem Cell Biol, Sheffield S10 2TN, S Yorkshire, England

[3] Univ So Calif, Keck Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90033 USA

[4] Lund Univ, Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, SE-22184 Lund, Sweden

[5] Weatherall Inst Mol Med, Mol Haematol Unit, Oxford OX3 9DS, England

[6] Lund Univ, Dept Theoret Phys, SE-22362 Lund, Sweden

来源：

CELL STEM CELL | 2009年 / 4卷 / 05期

基金：

英国医学研究理事会;

关键词：

SELF-RENEWAL; REGULATORY NETWORKS; LINEAGE-COMMITMENT; DIFFERENTIATION; PLURIPOTENCY; EPIBLAST; NICHE; IDENTIFICATION; HETEROGENEITY; SPECIFICATION;

D O I：

10.1016/j.stem.2009.04.011

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. The nature of the stem cell substates and their relationship to commitment to differentiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors.

引用

页码：387 / 397

页数：11

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