Evaluation of MMP3 and TIMP1 as candidate genes for high myopia in young Taiwanese men

被引：22

作者：

Liang, Chung-Ling

Wang, Hsin-Shih

Hung, Kuo-Sheng

Hsi, Edward

Sun, Angel

Kuo, Yi-Hui

Juo, Suh-Hang Hank

机构：

[1] Kaohsiung Med Univ, Grad Inst Med Genet, Kaohsiung 807, Taiwan

[2] Bright Eye Clin, Kaohsiung, Taiwan

[3] Chang Gung Mem Hosp, Grad Inst Clin Med Sci, Kaohsiung 83305, Taiwan

[4] Chang Gung Mem Hosp, Dept Surg, Kaohsiung 83305, Taiwan

[5] Kaohsiung Med Univ Hosp, Dept Clin Res, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ Hosp, Dept Ophthalmol, Kaohsiung, Taiwan

[7] Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 2006年 / 142卷 / 03期

关键词：

D O I：

10.1016/j.ajo.2006.03.063

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

PURPOSE: We studied the relationship between high myopia and the MMP3 and TIMP1 genes. DESIGN: Case,control study. METHODS: We enrolled 150 high myopic individuals (<= -6 diopters) and 262 controls (>= -1.5 diopters) initially, and another 216 cases and 474 controls were enrolled for genotyping promising polymorphisms for replication. Thirteen polymorphisms were genotyped in the initial data. Logistic regression was used to test for genetic effects. Subset analyses were performed according to the education level and family history. RESULTS: There was no significant association between any polymorphism and high myopia in the initial data. Among the highly educated subjects, the 5A/6A poly, morphism at the MMP3 gene suggested a potential relationship, with high myopia, and it was genotyped in the follow,up samples. However, this polymorphism failed to show any significant results in the overall subjects. CONCLUSIONS: The two genes may not play a crucial role for high myopia in young Taiwanese men.

引用

页码：518 / 520

页数：3

共 7 条

[1]

Scleral matrix metalloproteinases, serine proteinase activity and hydrational capacity are increased in myopia induced by retinal image degradation [J].