Protective effect of carbidopa on hydroxyl radical generation in the rat striatum by dopamine

被引:10
作者
Obata, T
Yamanaka, Y
机构
[1] Department of Pharmacology, Oita Medical University, Oita 879-55, 1-1, Hasama-machi
关键词
L-3,4-dihydroxyphenylalanine; carbidopa; dopamine; 3,4-dihydroxyphenylacetic acid; hydroxyl radical; brain dialysis;
D O I
10.1016/S0304-3940(96)13271-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of L-3,4-dihydroxyphenylalanine (L-DOPA) on the generation of hydroxyl free radicals (OH) was investigated using striatal microdialysis technique. Salicylic acid in Ringer's solution (0.5 nmol.mu l(-1).min(-1)) was infused directly through a microdialysis probe to detect the generation of OH as reflected by the formation of dihydroxybenzoic acids (DHBA) in the striatum. When L-DOPA (0.1 mM; 1 mu l.min(-1)) was infused in the rat brain, the level of 3,4-dihydroxyphenylacetic acid (DOPAC) gradually increased in a time-dependent manner. In addition, a marked elevation of DHBA was observed. However, in the presence of carbidopa, a decarboxylase inhibitor, the elevation in DHBA formation was not observed. These results suggest that carbidopa may suppress the OH generation by dopamine (DA). (C) 1996 Elsevier Science Ireland Ltd.
引用
收藏
页码:13 / 16
页数:4
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