Angiotensinogen in human essential hypertension

被引：47

作者：

Caulfield, M

Lavender, P

NewellPrice, J

Kamdar, S

Farrall, M

Clark, AJL

机构：

[1] UNIV LONDON ST BARTHOLOMEWS HOSP MED COLL,DEP MOL ENDOCRINOL ENDOCRINOL,LONDON EC1A 7BE,ENGLAND

[2] WELLCOME TRUST CTR HUMAN GENET,OXFORD,ENGLAND

来源：

HYPERTENSION | 1996年 / 28卷 / 06期

基金：

英国惠康基金;

关键词：

angiotensinogen; genetics; hypertension; essential;

D O I：

10.1161/01.HYP.28.6.1123

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, trans genic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.

引用

页码：1123 / 1125

页数：3

共 16 条

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