Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens

被引：54

作者：

Herold, BC

Siston, A

Bremer, J

Kirkpatrick, R

Wilbanks, G

Fugedi, P

Peto, C

Cooper, M

机构：

[1] RUSH UNIV, DEPT OBSTET & GYNECOL, CHICAGO, IL 60612 USA

[2] RUSH UNIV, DEPT MICROBIOL, CHICAGO, IL 60612 USA

[3] SO ILLINOIS UNIV, SCH MED, DEPT MED MICROBIOL & IMMUNOL, SPRINGFIELD, IL USA

[4] GLYCOMED INC, CARBOHYDRATE CHEM SECT, ALAMEDA, CA 94501 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 12期

关键词：

D O I：

10.1128/AAC.41.12.2776

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.

引用

收藏

页码：2776 / 2780

页数：5

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