DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms

被引：148

作者：

Feinberg, AP

Cui, HM

Ohlsson, R

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[5] Uppsala Univ, Dept Anim Dev & Genet, Uppsala, Sweden

来源：

SEMINARS IN CANCER BIOLOGY | 2002年 / 12卷 / 05期

关键词：

epigenetics; DNA methylation; genomic imprinting;

D O I：

10.1016/S1044-579X(02)00059-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since the discovery of epigenetic alterations in cancer 20 years ago by Feinberg and Vogelstein, a variety of such alterations have been found, including global hypomethylation, gene hypomethylation and hypermethylation, and loss of imprinting (LOI). LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting.

引用

页码：389 / 398

页数：10

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