共 48 条
Rationale for new treatments aimed at IgE immunomodulation
被引:39
作者:

Stokes, J
论文数: 0 引用数: 0
h-index: 0
机构:
Creighton Univ, Dept Med, Div Allergy Immunol, Omaha, NE 68131 USA Creighton Univ, Dept Med, Div Allergy Immunol, Omaha, NE 68131 USA

Casale, TB
论文数: 0 引用数: 0
h-index: 0
机构:
Creighton Univ, Dept Med, Div Allergy Immunol, Omaha, NE 68131 USA Creighton Univ, Dept Med, Div Allergy Immunol, Omaha, NE 68131 USA
机构:
[1] Creighton Univ, Dept Med, Div Allergy Immunol, Omaha, NE 68131 USA
关键词:
D O I:
10.1016/S1081-1206(10)61490-1
中图分类号:
R392 [医学免疫学];
学科分类号:
100102 ;
摘要:
Objective: To review potential or current therapies that decrease IgE synthesis or effects. Data Sources: Relevant literature in peer-reviewed journals and abstracts from national meetings. Study Selection: Key articles were selected by the authors. Results: Modulation of IgE-mediated diseases can occur at several levels. Transcription factors may be altered to differentiate lymphocytes into a T(H)1 phenotype, thus decreasing T(H)2-driven IgE production. This may be accomplished by inhibiting GATA-3 with peroxisome proliferator-activated receptor agonists or promoting T-bet expression with CpG motifs. Inhibiting IgE-promoting cytokines may be accomplished by blocking the effects or synthesis of interleukin 4 (IL-4) or IL-13 by suplatast tosilate. Cytokine therapy with anti-IL-4 or anti-IL-13 has the potential to directly influence IgE-mediated diseases, but strategies aimed at IL-4 alone have been disappointing. Clinical trials with interferon-gamma or IL-12, 2 cytokines important in promoting T(H)1 and inhibiting T(H)2 responses, have been fraught with adverse effects that make their use limited. The use of plasmids encoding interferon-gamma or IL-12 has shown promise in animal models. Inhibition of I-E synthesis has been demonstrated with anti-CD23 antibodies. Early human studies have been very encouraging, and larger studies are under way. The only IgE immunomodulator currently available for use is omalizumab. Omalizumab is effective for allergic asthma in children and adults. Conclusions: Newer therapies hold great promise for the future treatment of allergic respiratory diseases, but clinical trials are necessary to accurately evaluate risk-benefit ratios of IgE immunomodulators.
引用
收藏
页码:212 / 217
页数:6
相关论文
共 48 条
[1]
Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis
[J].
Ädelroth, E
;
Rak, S
;
Haahtela, T
;
Aasand, G
;
Rosenhall, L
;
Zetterstrom, O
;
Byrne, A
;
Champain, K
;
Thirlwell, J
;
Della Cioppa, G
;
Sandström, T
.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,
2000, 106 (02)
:253-259

Ädelroth, E
论文数: 0 引用数: 0
h-index: 0
机构:
Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Rak, S
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Haahtela, T
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Aasand, G
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Rosenhall, L
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Zetterstrom, O
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Byrne, A
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Champain, K
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Thirlwell, J
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Della Cioppa, G
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden

Sandström, T
论文数: 0 引用数: 0
h-index: 0
机构: Umea Univ Hosp, Dept Resp Med & Allergy, S-90185 Umea, Sweden
[2]
Regulation of peroxisome proliferator-activated receptor γ expression in human asthmatic airways -: Relationship with proliferation, apoptosis, and airway remodeling
[J].
Benayoun, L
;
Letuve, S
;
Druilhe, A
;
Boczkowski, J
;
Dombret, MC
;
Mechighel, P
;
Megret, J
;
Leseche, G
;
Aubier, M
;
Pretolani, M
.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,
2001, 164 (08)
:1487-1494

Benayoun, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

Letuve, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

论文数: 引用数:
h-index:
机构:

Boczkowski, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

Dombret, MC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

Mechighel, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

Megret, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

Leseche, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

Aubier, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France

Pretolani, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Paris 07, INSERM U408, F-75018 Paris, France
[3]
Interleukin-4 receptor in moderate atopic asthma - A phase I/II randomized, placebo-controlled trial
[J].
Borish, LC
;
Nelson, HS
;
Lanz, MJ
;
Claussen, L
;
Whitmore, JB
;
Agosti, JM
;
Garrison, L
.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,
1999, 160 (06)
:1816-1823

Borish, LC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Natl Jewish Med & Res Ctr, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

Nelson, HS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Natl Jewish Med & Res Ctr, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

Lanz, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Natl Jewish Med & Res Ctr, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

Claussen, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Natl Jewish Med & Res Ctr, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

Whitmore, JB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Natl Jewish Med & Res Ctr, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

Agosti, JM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Natl Jewish Med & Res Ctr, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

Garrison, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Natl Jewish Med & Res Ctr, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA
[4]
Experiences with monoclonal antibody therapy for allergic asthma
[J].
Boushey, HA
.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,
2001, 108 (02)
:S77-S83

Boushey, HA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA
[5]
Molecular and cellular mechanisms of allergic disease
[J].
Broide, DH
.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,
2001, 108 (02)
:S65-S71

Broide, DH
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Div Allergy & Immunol, La Jolla, CA 92093 USA Univ Calif San Diego, Div Allergy & Immunol, La Jolla, CA 92093 USA
[6]
Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
[J].
Bryan, SA
;
O'Connor, BJ
;
Matti, S
;
Leckie, MJ
;
Kanabar, V
;
Khan, J
;
Warrington, SJ
;
Renzetti, L
;
Rames, A
;
Bock, JA
;
Boyce, MJ
;
Hansel, TT
;
Holgate, ST
;
Barnes, PJ
.
LANCET,
2000, 356 (9248)
:2149-2153

Bryan, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

O'Connor, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Matti, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Leckie, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Kanabar, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Khan, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Warrington, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Renzetti, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Rames, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Bock, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Boyce, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Hansel, TT
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Holgate, ST
论文数: 0 引用数: 0
h-index: 0
机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England

Barnes, PJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England
[7]
The anti-IgE antibody omalizumab improves asthma-related quality of life in patients with allergic asthma
[J].
Buhl, R
;
Hanf, G
;
Solèr, M
;
Bensch, G
;
Wolfe, J
;
Everhard, F
;
Champain, K
;
Fox, H
;
Thirlwell, J
.
EUROPEAN RESPIRATORY JOURNAL,
2002, 20 (05)
:1088-1094

Buhl, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Hanf, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Solèr, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Bensch, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Wolfe, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Everhard, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Champain, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Fox, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Thirlwell, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Div Pulm, D-55131 Mainz, Germany
[8]
Omalizumab provides long-term control in patients with moderate-to-severe allergic asthma
[J].
Buhl, R
;
Solèr, M
;
Matz, J
;
Townley, R
;
O'Brien, J
;
Noga, O
;
Champain, K
;
Fox, H
;
Thirlwell, J
;
Della Cioppa, G
.
EUROPEAN RESPIRATORY JOURNAL,
2002, 20 (01)
:73-78

Buhl, R
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Solèr, M
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Matz, J
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Townley, R
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

O'Brien, J
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Noga, O
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Champain, K
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Fox, H
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Thirlwell, J
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany

Della Cioppa, G
论文数: 0 引用数: 0
h-index: 0
机构: Mainz Univ Hosp, Div Pulm, D-55131 Mainz, Germany
[9]
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
[J].
Busse, W
;
Corren, J
;
Lanier, BQ
;
McAlary, M
;
Fowler-Taylor, A
;
Della Cioppa, G
;
van As, A
;
Gupta, N
.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,
2001, 108 (02)
:184-190

Busse, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA

Corren, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA

Lanier, BQ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA

McAlary, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA

Fowler-Taylor, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA

Della Cioppa, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA

van As, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA

Gupta, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison, WI USA
[10]
CO-CROSS-LINKING FC-EPSILON-RII/CD23 AND B-CELL SURFACE-IMMUNOGLOBULIN MODULATES B-CELL ACTIVATION
[J].
CAMPBELL, KA
;
LEES, A
;
FINKELMAN, FD
;
CONRAD, DH
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
1992, 22 (08)
:2107-2112

CAMPBELL, KA
论文数: 0 引用数: 0
h-index: 0
机构: VIRGINIA COMMONWEALTH UNIV, DEPT MICROBIOL & IMMUNOL, BOX 678, MCV STN, RICHMOND, VA 23298 USA

LEES, A
论文数: 0 引用数: 0
h-index: 0
机构: VIRGINIA COMMONWEALTH UNIV, DEPT MICROBIOL & IMMUNOL, BOX 678, MCV STN, RICHMOND, VA 23298 USA

FINKELMAN, FD
论文数: 0 引用数: 0
h-index: 0
机构: VIRGINIA COMMONWEALTH UNIV, DEPT MICROBIOL & IMMUNOL, BOX 678, MCV STN, RICHMOND, VA 23298 USA

CONRAD, DH
论文数: 0 引用数: 0
h-index: 0
机构: VIRGINIA COMMONWEALTH UNIV, DEPT MICROBIOL & IMMUNOL, BOX 678, MCV STN, RICHMOND, VA 23298 USA