Self-assembly of the 2-His-1-carboxylate facial triad in mononuclear iron(II) and zinc(II) models of metalloenzyme active sites

被引：28

作者：

Friese, Seth J.

Kucera, Benjamin E.

Que, Lawrence, Jr.

Tolman, William B.

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Met Biocatalysis, Minneapolis, MN 55455 USA

来源：

INORGANIC CHEMISTRY | 2006年 / 45卷 / 20期

关键词：

D O I：

10.1021/ic061564s

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A synthetic strategy involving the use of sterically hindered N-donor and terphenylcarboxylate ligands has been used to prepare complexes of iron(II) and zinc(II) that feature N-2(carboxylate) donors. X-ray crystallographic and NMR data show that the 2-His-carboxylate facial triad found in metalloenzyme active sites is closely modeled by the mononuclear complexes. In addition, by virtue of the flexibility of the ligands used, the geometries and coordination environments of the complexes display carboxylate binding mode differences such as those seen in the enzymes.

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页码：8003 / 8005

页数：3

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