Lipid rafts: Feeling is believing

被引:54
作者
Henderson, RA [1 ]
Edwardson, JM [1 ]
Geisse, NA [1 ]
Saslowsky, DE [1 ]
机构
[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England
来源
NEWS IN PHYSIOLOGICAL SCIENCES | 2004年 / 19卷
关键词
D O I
10.1152/nips.01505.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In the late 1990s, accumulated evidence led to the proposal that biological membranes are composed of microdomains of different lipids, which form functional "rafts." Recent work using atomic force microscopy has given us new insights into the factors influencing the formation and behavior of these physiological microenvironments.
引用
收藏
页码:39 / 43
页数:5
相关论文
共 20 条
[1]   Lipid rafts reconstituted in model membranes [J].
Dietrich, C ;
Bagatolli, LA ;
Volovyk, ZN ;
Thompson, NL ;
Levi, M ;
Jacobson, K ;
Gratton, E .
BIOPHYSICAL JOURNAL, 2001, 80 (03) :1417-1428
[2]   Atomic-force microscopy: Rhodopsin dimers in native disc membranes [J].
Fotiadis, D ;
Liang, Y ;
Filipek, S ;
Saperstein, DA ;
Engel, A ;
Palczewski, K .
NATURE, 2003, 421 (6919) :127-128
[3]   Syncollin homo-oligomers associate with lipid bilayers in the form of doughnut-shaped structures [J].
Geisse, NA ;
Wäsle, B ;
Saslowsky, DE ;
Henderson, RM ;
Edwardson, JM .
JOURNAL OF MEMBRANE BIOLOGY, 2002, 189 (02) :83-92
[4]   Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy [J].
Lawrence, JC ;
Saslowsky, DE ;
Edwardson, JM ;
Henderson, RM .
BIOPHYSICAL JOURNAL, 2003, 84 (03) :1827-1832
[5]   MEMBRANE FLUIDITY AND ENZYME-ACTIVITIES IN BRUSH-BORDER AND BASOLATERAL MEMBRANES OF THE DOG KIDNEY [J].
LEGRIMELLEC, C ;
GIOCONDI, MC ;
CARRIERE, B ;
CARRIERE, S ;
CARDINAL, J .
AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 242 (03) :F246-F253
[6]   POLARIZED APICAL DISTRIBUTION OF GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED PROTEINS IN A RENAL EPITHELIAL-CELL LINE [J].
LISANTI, MP ;
SARGIACOMO, M ;
GRAEVE, L ;
SALTIEL, AR ;
RODRIGUEZBOULAN, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9557-9561
[7]   Spontaneous insertion and partitioning of alkaline phosphatase into model lipid rafts [J].
Milhiet, PE ;
Giocondi, MC ;
Baghdadi, O ;
Ronzon, F ;
Roux, B ;
Le Grimellec, C .
EMBO REPORTS, 2002, 3 (05) :485-490
[8]   Domain formation in models of the renal brush border membrane outer leaflet [J].
Milhiet, PE ;
Domec, C ;
Giocondi, MC ;
Van Mau, N ;
Heitz, F ;
Le Grimellec, C .
BIOPHYSICAL JOURNAL, 2001, 81 (01) :547-555
[9]   Determining molecular forces that stabilize human aquaporin-1 [J].
Möller, C ;
Fotiadis, D ;
Suda, K ;
Engel, A ;
Kessler, M ;
Müller, DJ .
JOURNAL OF STRUCTURAL BIOLOGY, 2003, 142 (03) :369-378
[10]   Observing membrane protein diffusion at subnanometer resolution [J].
Müller, DJ ;
Engel, A ;
Matthey, U ;
Meier, T ;
Dimroth, P ;
Suda, K .
JOURNAL OF MOLECULAR BIOLOGY, 2003, 327 (05) :925-930