AMBROXOL INHIBITS NEUTROPHIL RESPIRATORY BURST ACTIVATED BY ALPHA CHAIN INTEGRIN ADHESION

被引：14

作者：

Peroni, D. G. ^{[1
]}

Moser, S. ^{[1
]}

Gallo, G. ^{[1
]}

Pigozzi, R. ^{[1
]}

Tenero, L. ^{[1
]}

Zanoni, L. ^{[1
]}

Boner, A. L. ^{[1
]}

Piacentini, G. L. ^{[1
]}

机构：

[1] Univ Verona, Sez Pediat, Dipartimento Sci Vita & Riprod, I-37134 Verona, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2013年 / 26卷 / 04期

关键词：

oxidative stress; ambroxol; neutrophils; integrins; CELLS;

D O I：

10.1177/039463201302600406

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The purpose of the present study was to investigate the possible anti-oxidant effect(s) of Ambroxol on neutrophils activated by ligand-binding of the drug with membrane-associated adhesion integrin CD11a and to estimate dose-response changes in oxygen free radical production. The amount of free radical production by anti-CD11a- and anti-CD4-coated neutrophils stimulated with N-formyl-methionylleucyl-phenylalanine (FMLP) and challenged with increasing concentration of Ambroxol, was evaluated within a time frame of 90 minutes. A significant dose-dependent effect response of Ambroxol on O-2(-) production by cells coated with anti-CD11a antibody was observed. This preliminary study opens a new perspective on the therapeutic role of Ambroxol as an antioxidant drug and for its potential use in controlling oxidative stress, particularly in leukocyte-dependent inflammation.

引用

页码：883 / 887

页数：5

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