GPR40: Good Cop, Bad Cop?

被引:28
作者
Alquier, Thierry
Poitout, Vincent [1 ]
机构
[1] Univ Montreal, Ctr Hosp, CRCHUM, Montreal Diabet Res Ctr, Montreal, PQ, Canada
关键词
FATTY-ACID RECEPTOR; STIMULATED INSULIN-SECRETION; PANCREATIC BETA-CELLS; IN-VIVO; MICE; CALCIUM;
D O I
10.2337/db09-0215
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1035 / 1036
页数:2
相关论文
共 20 条
[1]   Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin [J].
Aston-Mourney, K. ;
Proietto, J. ;
Morahan, G. ;
Andrikopoulos, S. .
DIABETOLOGIA, 2008, 51 (04) :540-545
[2]   Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules [J].
Briscoe, Celia P. ;
Peat, Andrew J. ;
McKeown, Stephen C. ;
Corbett, David F. ;
Goetz, Aaron S. ;
Littleton, Thomas R. ;
McCoy, David C. ;
Kenakin, Terry P. ;
Andrews, John L. ;
Ammala, Carina ;
Fornwald, James A. ;
Ignar, Diane M. ;
Jenkinson, Stephen .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (05) :619-628
[3]   The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids [J].
Briscoe, CP ;
Tadayyon, M ;
Andrews, JL ;
Benson, WG ;
Chambers, JK ;
Eilert, MM ;
Ellis, C ;
Elshourbagy, NA ;
Goetz, AS ;
Minnick, DT ;
Murdock, PR ;
Sauls, HR ;
Shabon, U ;
Spinage, LD ;
Strum, JC ;
Szekeres, PG ;
Tan, KB ;
Way, JM ;
Ignar, DM ;
Wilson, S ;
Muir, AI .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :11303-11311
[4]   The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice [J].
Brownlie, Ruth ;
Mayers, Rachel M. ;
Pierce, Jackie A. ;
Marley, Anna E. ;
Smith, David M. .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 :950-954
[5]   Modulation of Osteoclastogenesis by Fatty Acids [J].
Cornish, Jillian ;
MacGibbon, Alastair ;
Lin, Jian-Ming ;
Watson, Maureen ;
Callon, Karen E. ;
Tong, P. C. ;
Dunford, James E. ;
van der Does, Yvonne ;
Williams, Garry A. ;
Grey, Andrew B. ;
Naot, Dorit ;
Reid, Ian R. .
ENDOCRINOLOGY, 2008, 149 (11) :5688-5695
[6]   Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion [J].
Edfalk, Sara ;
Steneberg, Par ;
Edlund, Helena .
DIABETES, 2008, 57 (09) :2280-2287
[7]   GPR40 is expressed in glucagon producing cells and affects glucagon secretion [J].
Flodgren, Erik ;
Olde, Bjorn ;
Meidute-Abaraviciene, Sandra ;
Winzell, Maria Sorhede ;
Ahren, Bo ;
Salehi, Albert .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 354 (01) :240-245
[8]   GPR40, a free fatty acid receptor on pancreatic β cells, regulates insulin secretion [J].
Itoh, Y ;
Hinuma, S .
HEPATOLOGY RESEARCH, 2005, 33 (02) :171-173
[9]   Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 [J].
Itoh, Y ;
Kawamata, Y ;
Harada, M ;
Kobayashi, M ;
Fujii, R ;
Fukusumi, S ;
Ogi, K ;
Hosoya, M ;
Tanaka, Y ;
Uejima, H ;
Tanaka, H ;
Maruyama, M ;
Satoh, R ;
Okubo, S ;
Kizawa, H ;
Komatsu, H ;
Matsumura, F ;
Noguchi, Y ;
Shinobara, T ;
Hinuma, S ;
Fujisawa, Y ;
Fujino, M .
NATURE, 2003, 422 (6928) :173-176
[10]   The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding [J].
Kebede, Melkam ;
Alquier, Thierry ;
Latour, Martin G. ;
Semache, Meriem ;
Tremblay, Caroline ;
Poitout, Vincent .
DIABETES, 2008, 57 (09) :2432-2437