Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma

被引:127
作者
Hwang, ES
Nyante, SJ
Chen, YY
Moore, D
DeVries, S
Korkola, JE
Esserman, LJ
Waldman, FM
机构
[1] Univ Calif San Francisco, Dept Pathol, Ctr Canc, San Francisco, CA 94115 USA
[2] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA
关键词
lobular carcinoma in situ; ductal carcinoma in situ; comparative genomic hybridization; breast neoplasms;
D O I
10.1002/cncr.20273
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts. However, the frequent association of LCIS with invasive lobular carcinoma (ILC) suggests a precursor-product relation. The possible genomic relation between synchronous LCIS and 3 ILC was analyzed using the technique of array-based comparative genomic hybridization (CGH). METHODS. Twenty-four samples from the University of California-San Francisco pathology archives that contained synchronous LCIS and ILC were identified. Array CGH was performed using random primer-amplified microdissected DNA. Samples were hybridized onto bacterial artificial chromosome arrays composed of approximately 2400 clones. Patterns of alterations within synchronous LCIS and 2 ILC were compared. RESULTS. A substantial proportion of the genome was altered in samples of both 3 LCIS and ILC. The most frequent alterations were gain of 1q and loss of 16q, both of which usually occurred as whole-arm changes. Smaller regions of gain and loss 4 were seen on other chromosome arms. Fourteen samples of LCIS were related more to their paired samples of ILC than to any other ILC, as demonstrated by a weighted similarity score. CONCLUSIONS. LCIS and ILC are neoplastic lesions that demonstrate a range of genomic alterations. In the current study, the genetic relation between synchronous LCIS and ILC suggested clonality in a majority of the paired specimens. These data were consistent with a progression pathway from LCIS to ILC. The authors conclude that LCIS, which is known to be a marker for an environment that is permissive of neoplasia, may itself represent a precursor to invasive carcinoma. (C) 2004 American Cancer Society.
引用
收藏
页码:2562 / 2572
页数:11
相关论文
共 36 条
[1]   E-cadherin is a tumour invasion suppressor gene mutated in human lobular breast cancers [J].
Berx, G ;
CletonJansen, AM ;
Nollet, F ;
deLeeuw, WJF ;
vandeVijver, MJ ;
Cornelisse, C ;
vanRoy, F .
EMBO JOURNAL, 1995, 14 (24) :6107-6115
[2]  
DeLeeuw WJF, 1997, J PATHOL, V183, P404, DOI 10.1002/(SICI)1096-9896(199712)183:4<404::AID-PATH1148>3.0.CO
[3]  
2-9
[4]   Loss of chromosome 16q in lobular carcinoma in situ [J].
Etzell, JE ;
Devries, S ;
Chew, K ;
Florendo, C ;
Molinaro, A ;
Ljung, BM ;
Waldman, FM .
HUMAN PATHOLOGY, 2001, 32 (03) :292-296
[5]   Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 study [J].
Fisher, B ;
Costantino, JP ;
Wickerham, DL ;
Redmond, CK ;
Kavanah, M ;
Cronin, WM ;
Vogel, V ;
Robidoux, A ;
Dimitrov, N ;
Atkins, J ;
Daly, M ;
Wieand, S ;
Tan-Chiu, E ;
Ford, L ;
Wolmark, N .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (18) :1371-1388
[6]  
Fisher ER, 1996, CANCER-AM CANCER SOC, V78, P1403, DOI 10.1002/(SICI)1097-0142(19961001)78:7<1403::AID-CNCR6>3.0.CO
[7]  
2-L
[8]  
Foote FW, 1941, AM J PATHOL, V17, P491
[9]   MANAGEMENT OF IN-SITU AND MINIMALLY INVASIVE BREAST-CARCINOMA [J].
FRYKBERG, ER ;
BLAND, KI .
WORLD JOURNAL OF SURGERY, 1994, 18 (01) :45-57
[10]  
Ginzinger DG, 2000, CANCER RES, V60, P5405