Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

被引：294

作者：

Sasai, Yoshiki ^{[1
]}

机构：

[1] RIKEN Ctr Dev Biol, Neurogenesis & Organogenesis Grp, Kobe, Hyogo 6500047, Japan

来源：

CELL STEM CELL | 2013年 / 12卷 / 05期

关键词：

IN-VITRO; 3-DIMENSIONAL CULTURE; ES CELLS; EFFICIENT DIFFERENTIATION; DIRECTED DIFFERENTIATION; DEFINITIVE ENDODERM; SELF-ORGANIZATION; SMALL-INTESTINE; MOUSE; PROGENITORS;

D O I：

10.1016/j.stem.2013.04.009

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The behavior of stem cells, when they work collectively, can be much more sophisticated than one might expect from their individual programming. This Perspective covers recent discoveries about the dynamic patterning and structural self-formation of complex organ buds in 3D stem cell culture, including the generation of various neuroectodermal and endodermal tissues. For some tissues, epithelial-mesenchymal interactions can also be manipulated in coculture to guide organogenesis. This new area of stem cell research-the spatiotemporal control of dynamic cellular interactions-will open a new avenue for next-generation regenerative medicine.

引用

页码：520 / 530

页数：11

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