Contribution of the Autolysin AtlA to the Bactericidal Activity of Amoxicillin against Enterococcus faecalis JH2-2

被引：11

作者：

Bravetti, Anne-Lise ^{[1
,2
,3
,4
]}

Mesnage, Stephane ^{[2
,3
,4
]}

Lefort, Agnes ^{[1
]}

Chau, Francoise ^{[1
]}

Eckert, Catherine ^{[2
,3
,4
]}

Garry, Louis ^{[5
]}

Arthur, Michel ^{[2
,3
,4
]}

Fantin, Bruno ^{[1
]}

机构：

[1] Univ Paris 07, Fac Med Xavier Bichat, EA3964, F-75018 Paris, France

[2] Univ Paris 06, Ctr Rech Cordeliers, UMRS 872, F-75006 Paris, France

[3] Univ Paris 05, UMRS 872, F-75006 Paris, France

[4] INSERM, U872, F-75006 Paris, France

[5] INSERM, U722, F-75018 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 04期

关键词：

CELL-WALL; ANTIBIOTICS; PENICILLIN; SUSCEPTIBILITY; RESISTANCE; MECHANISM;

D O I：

10.1128/AAC.00692-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bactericidal activity of amoxicillin was investigated against Enterococcus faecalis JH2-2 and against an isogenic mutant deficient in the production of the N-acetylglucosaminidase AtlA. Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis.

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收藏

页码：1667 / 1669

页数：3

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