Matrix metalloproteinases and their endogenous inhibitors in neuronal physiology of the adult brain

被引：245

作者：

Dzwonek, J

Rylski, M

Kaczmarek, L

机构：

[1] M Nencki Inst Expt Biol, Dept Mol & Cellular Neurobiol, PL-02093 Warsaw, Poland

[2] Univ Warmia & Mazury, Fac Biol, Dept Genet, PL-10719 Olsztyn, Poland

来源：

FEBS LETTERS | 2004年 / 567卷 / 01期

关键词：

brain; neuron; neuronal plasticity; long term potentiation; memory matrix metalloproteinase-9;

D O I：

10.1016/j.febslet.2004.03.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

More than 20 matrix metalloproteinases (MMPs) and four of their endogenous tissue inhibitors (TIMPs) act together to control tightly temporally restricted, focal proteolysis of extracellular matrix. In the neurons of the adult brain several components of the TIMP/MMP system are expressed and are responsive to changes in neuronal activity. Futhermore, functional studies, especially involving blocking of MMP activites, along with the identification of MMP substrates in the brain strongly suggest that this enzymatic system plays an important physiological role in adult brain neurons, possibly being pivotal for neuronal plasticity. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：129 / 135

页数：7

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