Normal differentiation and functions of mouse dendritic cells derived from RAG-deficient bone marrow progenitors

被引：12

作者：

Faure, M ^{[1
]}

Villiers, CL ^{[1
]}

Marche, PN ^{[1
]}

机构：

[1] Univ Grenoble 1, Commissariat Energie Atom Grenoble, INSERM, U548,Lab Immunochim, F-38000 Grenoble, France

来源：

CELLULAR IMMUNOLOGY | 2004年 / 228卷 / 01期

关键词：

dendritic cells; progenitors; cellular differentiation; T lymphocytes;

D O I：

10.1016/j.cellimm.2004.04.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dendritic cells (DC) mature upon infectious agent detection to elicit immune responses. It has been suggested that T cells influence peripheral DC function. However, it is not known if lymphocytes influence DC progenitors. Therefore, we determined the ability of bone marrow progenitors from T and B cell-deficient mice to generate functional DC. We report that bone marrow-derived DC from RAG-2(-/-) mice differentiate and proliferate normally. Moreover, such generated DC efficiently internalize particles, mature in response to various Toll-like receptor engagement, and activate allogenic T cells. This work strongly supports that early signals delivered during DC ontogeny by mature lymphocytes do not influence the functional differentiation of DC progenitors. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：8 / 14

页数：7

共 20 条

[1] Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo [J].