Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias

被引:39
作者
Chim, CS [1 ]
Wong, ASY [1 ]
Kwong, YL [1 ]
机构
[1] Queen Mary Hosp, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China
关键词
SOCS1; SHP1; Jak/STAT; acute leukaemias; methylation;
D O I
10.1007/s00277-004-0843-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
SOCS1 and SHP1 are negative regulators of the Jak/STAT signalling pathway that is implicated in leukaemogenesis. We studied if aberrant methylation of SOCS1 and SHP1 might be involved in the pathogenesis and prognostication of acute leukaemias by methylation-specific polymerase chain reaction (MSP). At diagnosis, methylation of SHP1 occurred more frequently in acute myeloid leukaemia (AML) (n=26, 52%) than acute lymphoblastic leukaemia (ALL) (n=6, 24%) (p=0.02). Methylation of SOCS1 was absent in both AML and ALL patients. SHP1 methylation was not associated with specific clinicopathologic features and had no prognostic impact on AML patients. Frequent methylation of SHP1, but not SOCS1, may be important in the pathogenesis, but not prognosis, of acute leukaemias.
引用
收藏
页码:527 / 532
页数:6
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