High Consistency of Regional Cortical Thinning in Aging across Multiple Samples

被引：506

作者：

Fjell, Anders M. ^{[1
,2
]}

Westlye, Lars T. ^{[1
]}

Amlien, Inge ^{[1
]}

Espeseth, Thomas ^{[1
]}

Reinvang, Ivar ^{[1
]}

Raz, Naftali ^{[3
,4
]}

Agartz, Ingrid ^{[5
,6
,7
]}

Salat, David H. ^{[8
]}

Greve, Doug N. ^{[8
]}

Fischl, Bruce ^{[8
,9
]}

Dale, Anders M. ^{[10
,11
,12
]}

Walhovd, Kristine B. ^{[1
,2
]}

机构：

[1] Univ Oslo, Dept Psychol, Ctr Study Human Cognit, N-0317 Oslo, Norway

[2] Ullevaal Univ Hosp, Dept Neuropsychol, N-0317 Oslo, Norway

[3] Wayne State Univ, Dept Psychol, Detroit, MI 48201 USA

[4] Wayne State Univ, Inst Gerontol, Detroit, MI 48201 USA

[5] Diakonhjemmet Hosp, Dept Psychiat Res, N-0319 Oslo, Norway

[6] Univ Oslo, Dept Psychiat, N-0319 Oslo, Norway

[7] Karolinska Hosp & Inst, HUBIN, Dept Clin Neurosci, Psychiat Sect, SE-17176 Stockholm, Sweden

[8] Massachusetts Gen Hosp, Athinoula A Martinos Ctr, Boston, MA 02129 USA

[9] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA

[10] Univ Calif San Diego, Multimodal Imaging Lab, San Diego, CA 92103 USA

[11] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA

[12] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA

来源：

CEREBRAL CORTEX | 2009年 / 19卷 / 09期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

aging; cortex; frontal lobes; morphometry; MRI; HUMAN CEREBRAL-CORTEX; AGE-RELATED DIFFERENCES; SURFACE-BASED ANALYSIS; HUMAN-BRAIN; ENTORHINAL CORTEX; HEALTHY-ADULTS; TEMPORAL-LOBE; OLDER-ADULTS; GREY-MATTER; MRI;

D O I：

10.1093/cercor/bhn232

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cross-sectional magnetic resonance imaging (MRI) studies of cortical thickness and volume have shown age effects on large areas, but there are substantial discrepancies across studies regarding the localization and magnitude of effects. These discrepancies hinder understanding of effects of aging on brain morphometry, and limit the potential usefulness of MR in research on healthy and pathological age-related brain changes. The present study was undertaken to overcome this problem by assessing the consistency of age effects on cortical thickness across 6 different samples with a total of 883 participants. A surface-based segmentation procedure (FreeSurfer) was used to calculate cortical thickness continuously across the brain surface. The results showed consistent age effects across samples in the superior, middle, and inferior frontal gyri, superior and middle temporal gyri, precuneus, inferior and superior parietal cortices, fusiform and lingual gyri, and the temporo-parietal junction. The strongest effects were seen in the superior and inferior frontal gyri, as well as superior parts of the temporal lobe. The inferior temporal lobe and anterior cingulate cortices were relatively less affected by age. The results are discussed in relation to leading theories of cognitive aging.

引用

页码：2001 / 2012

页数：12

共 75 条

[1] Aging in the CNS: Comparison of gray/white matter volume and diffusion tensor data [J].