The relation of amino-terminal propeptide of type III procollagen and severity of coronary artery disease in patients without myocardial infarction or hibernation

被引：18

作者：

Lin, Yen-Hung

Ho, Yi-Lwun

Wang, Tzung-Dau

Liu, Chung-Pin

Kao, Hsien-Li

Chao, Chia-Lun

Chien, Kuo-Liong

Hung, Chi-Sheng

Wu, Vin-Cent

Tsai, I-Jung

Yen, Ruoh-Fang

Shiau, Yu-Chien

Chen, Wen-Jone

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei 10016, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Internal Med, Yunlin Branch, Yunlin, Taiwan

[3] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Pediat, Taipei 10016, Taiwan

[6] Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan

[7] Far Eastern Mem Hosp, Dept Internal Med, Taipei, Taiwan

[8] Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan

[9] Yuans Gen Hosp, Dept Internal Med, Kaohsiung, Taiwan

来源：

CLINICAL BIOCHEMISTRY | 2006年 / 39卷 / 09期

关键词：

coronary artery disease; PINP; PIIINP; myocardial fibrosis;

D O I：

10.1016/j.clinbiochem.2006.05.017

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: The association of cardiac fibrosis and coronary artery disease (CAD) in patients without infarction or hibernation is unclear. We investigated the relationship between serum concentrations of procollagen propeptides and severity of CAD in such patients. Design and methods: Forty-six patients (32 men; mean age 64 years) with chest pain were enrolled. All patients received stress thallium-201 single photon emission computed tomography (SPECT) and analysis of the serum levels of the amino-terminal propeptide of type I and III procollagen (PINP and PIIINP). Results: In patients with thallium-201 perfusion defects, the number of diseased vessels was associated significantly with PIIINP (p=0.024) rather than PINP (p=0.613). Follow-up serum PINP and PIIINP levels after coronary intervention (mean 84 days) revealed no significant decrease. Conclusions: Serum PIIINP level is significantly associated with the severity of CAD in patients without myocardial infarction or hibernation. (c) 2006 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：861 / 866

页数：6

共 27 条

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