Coumarins and bicoumarin from Ferula sumbul:: anti-HIV activity and inhibition of cytokine release

被引：260

作者：

Zhou, P

Takaishi, Y

Duan, HQ

Chen, B

Honda, G

Itoh, M

Takeda, Y

Kodzhimatov, OK

Lee, KH

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Kyoto Univ, Fac Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[3] Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 770, Japan

[4] Uzbek Acad Sci, Uzbekistan Inst Bot, Tashkent 700143, Uzbekistan

[5] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 06期

关键词：

Ferula sumbul; Umbelliferae; coumarin; bicoumarin; fesumtuorin;

D O I：

10.1016/S0031-9422(99)00554-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：689 / 697

页数：9

共 24 条

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COUMARIN CONSTITUENTS OF SELINUM-TENUIFOLIUM [J].