Synthesis and phenotypic screening of a guanine-mimetic library

被引：6

作者：

Miller, SC ^{[1
]}

Mitchison, TJ

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Inst Chem & Cell Biol, Boston, MA 02115 USA

来源：

CHEMBIOCHEM | 2004年 / 5卷 / 07期

关键词：

chemical biology; combinatorial chemistry; fluorescence microscopy; guanine mimetics; solid-phase synthesis;

D O I：

10.1002/cbic.200400039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Going for guanine. We have synthesized a split-pool library of guanine-mimetics. Phenotypic screening of this library in mammalian tissue culture cells by fluorescence microscopy revealed several unique bioactive compounds, see scheme.

引用

页码：1010 / 1012

页数：3

共 10 条

[1] The 1.25 Å crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters [J].

Auerbach, G ;

Herrmann, A ;

Gütlich, M ;

Fischer, M ;

Jacob, U ;

Bacher, A ;

Huber, R .

EMBO JOURNAL, 1997, 16 (24) :7219-7230

[2] Rearrangement of 4-imino-4H-3,1-benzoxazines to 4-quinazolinones via amidine carboxamides [J].

He, F ;

Snider, BB .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (04) :1397-1399

[3] ANTIMITOTIC AGENTS - CHEMISTRY AND RECOGNITION OF TUBULIN MOLECULE [J].

IWASAKI, S .

MEDICINAL RESEARCH REVIEWS, 1993, 13 (02) :183-198

[4] Protein kinase inhibitors: The tyrosine-specific protein kinases [J].

Lawrence, DS ;

Niu, JK .

PHARMACOLOGY & THERAPEUTICS, 1998, 77 (02) :81-114

[5]

Meyer EA, 2002, CHEMBIOCHEM, V3, P250, DOI 10.1002/1439-7633(20020301)3:2/3<250::AID-CBIC250>3.0.CO

[6]

2-J

[7]

MILLER SR, UNPUB

[8] NEW METHODOLOGY FOR THE PREPARATION OF QUINAZOLINE DERIVATIVES VIA TANDEM AZA-WITTIG/HETEROCUMULENE-MEDIATED ANNULATION - SYNTHESIS OF 4(3H)-QUINAZOLINONES, BENZIMIDAZO[1,2-C]QUINAZOLINES, QUINAZOLINO[3,2-A]QUINAZOLINES AND BENZOTHIAZOLO[3,2-C]QUINAZOLINES [J].

MOLINA, P ;

ALAJARIN, M ;

VIDAL, A ;

FOCESFOCES, MD ;

CANO, FH .

TETRAHEDRON, 1989, 45 (13) :4263-4286

[9]

Villalgordo JM, 1998, SYNLETT, P1405

[10] A traceless approach for the parallel solid-phase synthesis of 2-(arylamino)quinazolinones [J].

Yu, YP ;

Ostresh, JM ;

Houghten, RA .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (16) :5831-5834

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