Adhesion within the stem cell niches

被引:81
作者
Raymond, Karine [1 ]
Deugnier, Marie-Ange [1 ]
Faraldo, Marisa M. [1 ]
Glukhova, Marina A. [1 ]
机构
[1] CNRS, UMR144, F-75248 Paris 05, France
关键词
SELF-RENEWAL; DROSOPHILA OVARY; MAMMARY-GLAND; N-CADHERIN; TENASCIN-C; SKIN; DIFFERENTIATION; EXPRESSION; BETA-1-INTEGRIN; MAINTENANCE;
D O I
10.1016/j.ceb.2009.05.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Growing body of evidence confirms that cell-cell and cell-extracellular matrix adhesion within stem cell niches is essential for the establishment and maintenance of niche architecture, for the generation and transmission of short-distance regulatory signals, and for controlling the frequency and nature of stem cell divisions. Recent studies demonstrated that in many stem cell niches, adhesion to support cells and/or extracellular matrix determines orientation of stem cell division plane, thereby contributing to the control of stem cell self-renewal and differentiation. Thus, although further analysis of the implicated molecular mechanisms is required, cadherin-associated and integrin-associated events appear to play essential regulatory roles in tissue-specific stem cell niches.
引用
收藏
页码:623 / 629
页数:7
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