Impact of simian immunodeficiency virus (SIV) infection on lymphocyte numbers and T-cell turnover in different organs of rhesus monkeys

被引:52
作者
Sopper, S
Nierwetberg, D
Halbach, A
Sauer, U
Scheller, C
Stahl-Hennig, C
Mätz-Rensing, K
Schäfer, F
Schneider, T
ter Meulen, V
Müller, JG
机构
[1] Univ Wurzburg, Inst Virol & Immunbiol, D-97078 Wurzburg, Germany
[2] Deutsch Primatenzentrum GmbH, Gottingen, Germany
[3] Univ Saarland, Homburg, Germany
[4] Univ Wurzburg, Inst Pathol, D-8700 Wurzburg, Germany
关键词
D O I
10.1182/blood-2002-06-1644
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
HIV infection leads to reduced numbers and increased turnover of CD4(+) T cells in blood. However, blood represents only 2% of the total lymphocyte pool, and information about other organs is lacking, leading to controversy about the effects of HIV infection on T-cell homeostasis. Therefore, we have determined phenotype and turnover of lymphocyte subsets in various tissues of macaques. Infection with simian immunodeficiency virus (SIV) resulted in increased proliferation rates of T cells in all organs. Despite reduced CD4 counts in blood, absolute numbers of CD4(+) T cells were increased in spleen and lymph nodes and remained stable in nonlymphoid organs such as liver, lung, bone marrow, and brain during the asymptomatic phase, indicative for an altered tissue distribution. In animals killed with first signs of AIDS, total body CD4 counts and proliferation rates had returned to control levels, whereas thymocytes were almost completely absent. Our data show that a drastically increased turnover in the early stages of HIV infection, driven by a generalized immune activation rather than a homeostatic response to CD4(+) T-cell destruction, is followed by exhaustion of the regenerative capacity of the immune system. (C) 2003 by The American Society of Hematology.
引用
收藏
页码:1213 / 1219
页数:7
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