Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

被引：10

作者：

Gong, Gangli ^{[1
]}

Xie, Yuli ^{[1
]}

Liu, Yidong ^{[1
]}

Rinderspacher, Alison ^{[1
]}

Deng, Shi-Xian ^{[1
]}

Feng, Yan ^{[1
]}

Zhu, Zhengxiang ^{[1
]}

Tang, Yufei ^{[1
]}

Wyler, Michael ^{[2
]}

Aulner, Nathalie ^{[2
]}

Toebben, Udo ^{[2
]}

Smith, Deborah H. ^{[2
]}

Branden, Lars ^{[2
]}

Chung, Caty ^{[3
]}

Schrer, Stephan ^{[3
]}

Vidovic, Dusica ^{[3
]}

Landry, Donald W. ^{[1
]}

机构：

[1] Columbia Univ, Dept Med, New York, NY 10032 USA

[2] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA

[3] Scripps Res Inst, Jupiter, FL 33458 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NF-kappa B; Activator; Quinazoline; HUVEC cells; INHIBITORS; AGENTS;

D O I：

10.1016/j.bmcl.2008.12.086

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An IKK beta inhibitor reported to block NF-kappa B transcriptional activities in Jurkat T cells, was found to enhance NF-kappa B translocation in HUVEC cells. These studies suggested a noncanonical NF-kappa B signaling pathway independent of IKK beta in HUVEC cells. (C) 2009 Published by Elsevier Ltd.

引用

收藏

页码：1191 / 1194

页数：4

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