Presynaptic long-term depression at the hippocampal mossy fiber-CA3 synapse

被引：133

作者：

Kobayashi, K ^{[1
]}

Manabe, T ^{[1
]}

Takahashi, T ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,INST BRAIN RES,BUNKYO KU,TOKYO 113,JAPAN

来源：

SCIENCE | 1996年 / 273卷 / 5275期

关键词：

D O I：

10.1126/science.273.5275.648

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength may underlie learning and memory in the brain. The induction of LTP occurs in postsynaptic cells in the hippocampal CA1 region but is presynaptic in CA3. LTD is also well characterized in CA1 but not in CA3. Low-frequency stimulation of mouse hippocampal slices caused homosynaptic LTD at the messy fiber-CA3 synapse, which may be induced presynaptically by activation of metabotropic glutamate receptors. Thus, the efficacy of messy fiber-CA3 synapses can be regulated bidirectionally, which may contribute to neuronal information processing.

引用

页码：648 / 650

页数：3

共 33 条

[1] DEVELOPMENTAL SHIFT FROM LONG-TERM DEPRESSION TO LONG-TERM POTENTIATION AT THE MOSSY FIBER SYNAPSES IN THE RAT HIPPOCAMPUS
BATTISTIN, T
CHERUBINI, E
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (11) : 1750 - 1755
[2] POSTSYNAPTIC INDUCTION AND PRESYNAPTIC EXPRESSION OF HIPPOCAMPAL LONG-TERM DEPRESSION
BOLSHAKOV, VY
SIEGELBAUM, SA
[J]. SCIENCE, 1994, 264 (5162) : 1148 - 1152
[3] LONG-TERM POTENTIATION IN HIPPOCAMPAL CA3 NEURONS - TETANIZED INPUT REGULATES HETEROSYNAPTIC EFFICACY
BRADLER, JE
BARRIONUEVO, G
[J]. SYNAPSE, 1989, 4 (02) : 132 - 142
[4] THE ROLE OF CA2+ CHANNELS IN HIPPOCAMPAL MOSSY FIBER SYNAPTIC TRANSMISSION AND LONG-TERM POTENTIATION
CASTILLO, PE
WEISSKOPF, MG
NICOLL, RA
[J]. NEURON, 1994, 12 (02) : 261 - 269
[5] HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF HIPPOCAMPUS AND EFFECTS OF N-METHYL-D-ASPARTATE RECEPTOR BLOCKADE
DUDEK, SM
BEAR, MF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) : 4363 - 4367
[6] GUERINEAU NC, 1995, J NEUROSCI, V15, P4395
[7] LONG-TERM POTENTIATION OF GUINEA-PIG MOSSY FIBER RESPONSES IS NOT BLOCKED BY N-METHYL D-ASPARTATE ANTAGONISTS
HARRIS, EW
COTMAN, CW
[J]. NEUROSCIENCE LETTERS, 1986, 70 (01) : 132 - 137
[8] INDUCTION OF LTD BUT NOT LTP THROUGH METABOTROPIC GLUTAMATE RECEPTORS IN VISUAL-CORTEX
HARUTA, H
KAMISHITA, T
HICKS, TP
TAKAHASHI, MP
TSUMOTO, T
[J]. NEUROREPORT, 1994, 5 (14) : 1829 - 1832
[9] HAYASHI Y, 1994, J NEUROSCI, V14, P3370
[10] ROLES OF GLUTAMATE RECEPTORS IN LONG-TERM POTENTIATION AT HIPPOCAMPAL MOSSY FIBER SYNAPSES
ITO, I
SUGIYAMA, H
[J]. NEUROREPORT, 1991, 2 (06) : 333 - 336

← 1 2 3 4 →