Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteer

被引：35

作者：

Lee, Grace A.

Lo, Joan C.

Aweeka, Francesca

Schwarz, Jean-Marc

Mulligan, Kathleen

Schambelan, Morris

Grunfeld, Carl

机构：

[1] Dept VAMC, Metab Sect, San Francisco, CA 94121 USA

[2] Dept VAMC, Endocrine Sect, San Francisco, CA 94121 USA

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Pharmacol, San Francisco, CA 94143 USA

[5] San Francisco Gen Hosp, Div Endocrinol, San Francisco, CA 94110 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2006年 / 43卷 / 05期

关键词：

D O I：

10.1086/505974

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previously, we found that 4 weeks of treatment with lopi-navir-ritonavir did not decrease insulin sensitivity but did increase adiponectin levels. In the present study, a single dose of lopinavir-ritonavir decreases insulin sensitivity but does not alter adiponectin levels. Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect.

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收藏

页码：658 / 660

页数：3

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