Chalk and cheese:: symptomatic hypocalcaemia during paediatric anti-tuberculous therapy

被引：5

作者：

Burgner, D

Schölvinck, E

Coren, M

Walters, S

机构：

[1] Univ Western Australia, Princess Margaret Med Ctr, Sch Paediat & Child Hlth, Perth, WA 6840, Australia

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, St Marys Hosp, Dept Paediat, London W2 1PG, England

来源：

JOURNAL OF INFECTION | 2004年 / 49卷 / 02期

关键词：

tuberculosis; isoniazid; rifampicin; hypocalcaemia; vitamin D;

D O I：

10.1016/j.jinf.2003.11.012

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Standard anti-tuberculosis therapy may disrupt normal vitamin D metabolism and consequently calcium homeostasis, but this is previously unreported in paediatric patients. We describe two children developed symptomatic hypocalcaemia secondary to hypovitaminosis D, which had been precipitated by rifampicin and isoniazid. The complex relationship between tuberculosis, anti-tuberculosis therapy, vitamin D metabolism and calcium, together with the clinical implications, are discussed. (C) 2003 The British Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：169 / +

页数：9

共 20 条

[1] Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene [J].