Molecular analysis of the interaction between HPV type 16 E6 and human E6-associated protein

被引：18

作者：

Daniels, PR

Sanders, CM

Coulson, P

Maitland, NJ

机构：

[1] UNIV YORK,CANC RES UNIT,YCRC,YORK YO1 5YW,N YORKSHIRE,ENGLAND

[2] UNIV YORK,DEPT BIOL,YORK YO1 5YW,N YORKSHIRE,ENGLAND

来源：

FEBS LETTERS | 1997年 / 416卷 / 01期

关键词：

human papillomavirus; E6; E6-associated protein; crosslinking;

D O I：

10.1016/S0014-5793(97)01160-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complex formed between the human papillomavirus type 16 E6 protein and human E6-associated protein, which combine to ubiquitylate and degrade p53, has been studied bg chemical crosslinking. Analysis of the interactions of proteins purified from Escherichia coli as wen as proteins expressed in insect cells indicates that, while E6 has the capacity to form dimers, E6 and E6-associated protein interact as two monomers to form a heterologous dimer. (C) 1997 Federation of European Biochemical Societies.

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页码：6 / 10

页数：5

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